It depends on the question.
Say the question is about applying math, like:
How do I find the average income given a Lorenz curve?
Then clearly no: this should go to Economics, or even Math, if you can abstract the question from the particular economical context.
If it's a question about philosophy of science, for example:
Is this falsification of that theorem correct?
Then, yes, but I don't think this is the type of question you're getting at.
Lately we have had some questions of the type:
How can I be sure that this mathematical model represents that real life situation properly?
Which is borderline. In my opinion and experience, the best answers to those questions are found on other sites, where they deal with that specific field (economy, physics, etc.), but when phrased as a philosophical question it wouldn't be off topic here.
Note that for example Math and Physics have a soft-question tag which can be used for somewhat more meta level questions.